"ଡୁଟାସ୍ଟେରାଇଡ" ପୃଷ୍ଠାର ସଂସ୍କରଣଗୁଡ଼ିକ ମଧ୍ୟରେ ତଫାତ
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ଅଧିକ ତଥ୍ୟ ଦିଆଗଲା |
ଅଧିକ ତଥ୍ୟ ଦିଆଗଲା |
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୧ କ ଧାଡ଼ି:
{{ଛୋଟ|Dutasteride}}
{{Drugbox
| Verifiedfields = verified
୨୪ କ ଧାଡ଼ି:
| metabolism = [[Liver]] ([[CYP3A4]])<ref name="LemkeWilliams2008" />
| metabolites = • 4'-Hydroxydutasteride<ref name="LemkeWilliams2008" /><br />• 6'-Hydroxydutasteride<ref name="LemkeWilliams2008" /><br />• 1,2-Dihydrodutasteride<ref name="LemkeWilliams2008" /><br />(All three active)<ref name="LemkeWilliams2008" />
| elimination_half-life = 4–5 weeks <ref name=Blu2008 /><ref name="BurchumRosenthal2014">{{cite book|author1=Jacqueline Burchum|author2=Laura Rosenthal|title=Lehne's Pharmacology for Nursing Care|url=https://books.google.com/books?id=C7_NBQAAQBAJ&pg=PA803|date=2 December 2014|publisher=Elsevier Health Sciences|isbn=978-0-323-34026-7|pages=803–}}</ref>
| excretion = [[Feces]]: 40% ([[metabolite]]s)<ref name="LemkeWilliams2008" /><br />[[Urine]]: 5% (unchanged)<ref name="LemkeWilliams2008">{{cite book|author1=Thomas L. Lemke|author2=David A. Williams|title=Foye's Principles of Medicinal Chemistry|url=https://books.google.com/books?id=R0W1ErpsQpkC&pg=PA1286|year=2008|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-6879-5|pages=1286–1287}}</ref>
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୬୧ କ ଧାଡ଼ି:
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ଡୁଟାସ୍ଟେରାଇଡର ସାଧାରଣ ପ୍ରତିକ୍ରିୟାରେ ଯୌନ ସମସ୍ୟା, ସ୍ତନ ଦରଜ ଓ ସ୍ତନ ବୃଦ୍ଧି ହୋଇପାରେ ।<ref name=AHFS2019/> ଏହା ବ୍ୟତୀତ କେତେକ ପ୍ରକାରର [[ପ୍ରୋସ୍ଟେଟ କର୍କଟ]], [[ଅବସାଦ]] ଓ [[ଆଞ୍ଜିଓଇଡିମା]] ହୋଇପାରେ ।<ref name=AHFS2019/><ref name=BNF76/> [[ଗର୍ଭାବସ୍ଥା]]ରେ ଓ ଯୌନ ସାଥୀ ଏହାର ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୁଏ ।<ref name=AHFS2019/><ref name=BNF76/> ଡୁଟାସ୍ଟେରାଇଡ ଏକ ପ୍ରକାର [[୫ -ରିଡକ୍ଟେଜ ଇନହିବିଟର]] ([[:en:5α-reductase inhibitor|5α-reductase inhibitor]]) ଓ ଏକ [[ଆଣ୍ଟିଆଣ୍ଡ୍ରୋଜେନ]] ([[:en:antiandrogen|antiandrogen]]) ଔଷଧ ।<ref name=Blu2008>{{cite book|author1=Ulrike Blume-Peytavi|author2=David A. Whiting|author3=Ralph M. Trüeb|title=Hair Growth and Disorders|url=https://books.google.com/books?id=pHrX2-huQCoC&pg=PA369|date=26 June 2008|publisher=Springer Science & Business Media|isbn=978-3-540-46911-7|pages=182, 369}}</ref> ଏହା ଏକ ଏଞ୍ଜାଇମ ଇନହିବିଟର ([[:en:enzyme inhibitor|decreasing|]]) ଯାହା [[ଡାଇହାଇଡ୍ରୋଟେସ୍ଟୋସ୍ଟିରନ]] ([[:en:dihydrotestosterone|dihydrotestosterone]]/ DHT) ନାମକ ଏକ ପ୍ରକାର ଯୌନ ହରମୋନ ([[:en:sex hormone|sex hormone]]) ଆଣ୍ଡ୍ରୋଜେନର ([[:en:androgen|androgen]]) ବାୟୋସିନ୍ଥେସିସ ([[:en:biosynthesis|production|]]) କମେଇ ଦେଇ କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।<ref name=Agg2010>{{cite journal | vauthors = Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M | title = An overview on 5alpha-reductase inhibitors | journal = Steroids | volume = 75 | issue = 2 | pages = 109–53 | date = February 2010 | pmid = 19879888 | doi = 10.1016/j.steroids.2009.10.005 }}</ref><ref name=AHFS2019/>
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Dutasteride
==ଆଧାର==
{{ଆଧାର}}
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