"ଡୁଟାସ୍ଟେରାଇଡ" ପୃଷ୍ଠାର ସଂସ୍କରଣ‌ଗୁଡ଼ିକ ମଧ୍ୟରେ ତଫାତ

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ଅଧିକ ତ‌ଥ୍ୟ ଦିଆଗଲା
ଅଧିକ ତ‌ଥ୍ୟ ଦିଆଗଲା
୧ କ ଧାଡ଼ି:
{{ଛୋଟ|Dutasteride}}{{ଲେଖା ଚାଲିଛି}}
{{Drugbox
| Verifiedfields = verified
୨୪ କ ଧାଡ଼ି:
| metabolism = [[Liver]] ([[CYP3A4]])<ref name="LemkeWilliams2008" />
| metabolites = • 4'-Hydroxydutasteride<ref name="LemkeWilliams2008" /><br />• 6'-Hydroxydutasteride<ref name="LemkeWilliams2008" /><br />• 1,2-Dihydrodutasteride<ref name="LemkeWilliams2008" /><br />(All three active)<ref name="LemkeWilliams2008" />
| elimination_half-life = 4–5 weeks <ref name=Blu2008 /><ref name="BurchumRosenthal2014">{{cite book|author1=Jacqueline Burchum|author2=Laura Rosenthal|title=Lehne's Pharmacology for Nursing Care|url=https://books.google.com/books?id=C7_NBQAAQBAJ&pg=PA803|date=2 December 2014|publisher=Elsevier Health Sciences|isbn=978-0-323-34026-7|pages=803–}}</ref>
| elimination_half-life = 4–5 weeks<ref name="BurchumRosenthal2014" /><ref name=Blu2008 />
| excretion = [[Feces]]: 40% ([[metabolite]]s)<ref name="LemkeWilliams2008" /><br />[[Urine]]: 5% (unchanged)<ref name="LemkeWilliams2008">{{cite book|author1=Thomas L. Lemke|author2=David A. Williams|title=Foye's Principles of Medicinal Chemistry|url=https://books.google.com/books?id=R0W1ErpsQpkC&pg=PA1286|year=2008|publisher=Lippincott Williams & Wilkins|isbn=978-0-7817-6879-5|pages=1286–1287}}</ref>
 
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୬୧ କ ଧାଡ଼ି:
 
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ଡୁଟାସ୍ଟେରାଇଡର ସାଧାରଣ ପ୍ରତିକ୍ରିୟାରେ ଯୌନ ସମସ୍ୟା, ସ୍ତନ ଦରଜ ଓ ସ୍ତନ ବୃଦ୍ଧି ହୋଇପାରେ ।<ref name=AHFS2019/> ଏହା ବ୍ୟତୀତ କେତେକ ପ୍ରକାରର [[ପ୍ରୋସ୍ଟେଟ କର୍କଟ]], [[ଅବସାଦ]] ଓ [[ଆଞ୍ଜିଓଇଡିମା]] ହୋଇପାରେ ।<ref name=AHFS2019/><ref name=BNF76/> [[ଗର୍ଭାବସ୍ଥା]]ରେ ଓ ଯୌନ ସାଥୀ ଏହାର ବ୍ୟବ‌ହାର କଲେ ଶିଶୁର କ୍ଷତି ହୁଏ ।<ref name=AHFS2019/><ref name=BNF76/> ଡୁଟାସ୍ଟେରାଇଡ ଏକ ପ୍ରକାର [[୫ -ରିଡକ୍ଟେଜ ଇନହିବିଟର]] ([[:en:5α-reductase inhibitor|5α-reductase inhibitor]]) ଓ ଏକ [[ଆଣ୍ଟିଆଣ୍ଡ୍ରୋଜେନ]] ([[:en:antiandrogen|antiandrogen]]) ଔଷଧ ।<ref name=Blu2008>{{cite book|author1=Ulrike Blume-Peytavi|author2=David A. Whiting|author3=Ralph M. Trüeb|title=Hair Growth and Disorders|url=https://books.google.com/books?id=pHrX2-huQCoC&pg=PA369|date=26 June 2008|publisher=Springer Science & Business Media|isbn=978-3-540-46911-7|pages=182, 369}}</ref> ଏହା ଏକ ଏଞ୍ଜାଇମ ଇନହିବିଟର ([[:en:enzyme inhibitor|decreasing|]]) ଯାହା [[ଡାଇହାଇଡ୍ରୋଟେସ୍ଟୋସ୍ଟିରନ]] ([[:en:dihydrotestosterone|dihydrotestosterone]]/ DHT) ନାମକ ଏକ ପ୍ରକାର ଯୌନ ହରମୋନ ([[:en:sex hormone|sex hormone]]) ଆଣ୍ଡ୍ରୋଜେନର ([[:en:androgen|androgen]]) ବାୟୋସିନ୍ଥେସିସ ([[:en:biosynthesis|production|]]) କମେଇ ଦେଇ କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।<ref name=Agg2010>{{cite journal | vauthors = Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M | title = An overview on 5alpha-reductase inhibitors | journal = Steroids | volume = 75 | issue = 2 | pages = 109–53 | date = February 2010 | pmid = 19879888 | doi = 10.1016/j.steroids.2009.10.005 }}</ref><ref name=AHFS2019/>
 
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Dutasteride wasସନ patented୧୯୯୩ରେ in 1993 by[[ଗ୍ଲାକ୍ସୋସ୍ମିଥକ୍ଲାଇନ]]ଦ୍ୱାରା ([[:en:GlaxoSmithKline|GlaxoSmithKline]]) andପେଟେଣ୍ଟ wasହେବା approvedପରେ forସନ medical୨୦୦୧ରେ useଡାକ୍ତରୀ inବ୍ୟବ‌ହାର 2001.ନିମନ୍ତେ ସ୍ୱୀକୃତ ହୋଇଥିଲା ।<ref name=Fis2006>{{cite book |last1=Fischer |first1=Jnos |last2=Ganellin |first2=C. Robin |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=483 |url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA483 |language=en}}</ref><ref name=AHFS2019/> Itଏହା is[[ଜେନେରିକ avaliableଔଷଧ as aନାମ]]ରେ ([[:en:generic medication|generic medication]].) ବିକ୍ରୟ ହୁଏ ।<ref name=BNF76/> Aସନ month୨୦୧୯ରେ supplyସଂଯୁକ୍ତ inରାଷ୍ଟ୍ରରେ the([[:en:United Kingdom|United Kingdom]]) costs the[[ଏନଏଚଏସ]]କୁ ([[:en:NHS|NHS]]) aboutଏହାର 12ଏକ £ମାସର asଡୋଜ ofପିଛା 2019.ପ୍ରାୟ ୧୨ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ କରିବାକୁ ପଡ଼ୁଥିଲା ।<ref name=BNF76/> Inଯୁକ୍ତରାଷ୍ଟ୍ର theଆମେରିକାରେ Unitedଏହାର Statesଏକ theମାସ wholesaleଡୋଜର costହୋଲସେଲ ofମୂଲ୍ୟ this୬.୬୬ amountଆମେରିକୀୟ isଡଲାର about 6.66 USD.<ref name=NADAC2019>{{cite web |title=NADAC as of 2019-02-27 |url=https://data.medicaid.gov/Drug-Pricing-and-Payment/NADAC-as-of-2019-02-27/s7c9-pfa6 |website=Centers for Medicare and Medicaid Services |accessdate=3 March 2019 |language=en}}</ref> Inସନ 2016୨୦୧୬ରେ itଏହାର was theନିୟୁତରୁ 274thଅଧିକ mostପ୍ରେସକ୍ରିପସନ prescribedହୋଇ medicationସର୍ବାଧିକ inପ୍ରେସକ୍ରିସନ theତାଲିକାର United୨୭୪ତମ Statesସ୍ଥାନରେ withଥଲା more than a million prescriptions.<ref>{{cite web |title=The Top 300 of 2019 |url=https://clincalc.com/DrugStats/Top300Drugs.aspx |website=clincalc.com |accessdate=22 December 2018}}</ref>
 
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==ଆଧାର==
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