"ଡୁଟାସ୍ଟେରାଇଡ" ପୃଷ୍ଠାର ସଂସ୍କରଣଗୁଡ଼ିକ ମଧ୍ୟରେ ତଫାତ
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'''ଡୁଟାସ୍ଟେରାଇଡ''' ([[ଇଂରାଜୀ ଭାଷା]]ରେ '''Dutasteride''', ଏକ ବିକ୍ରୟ ନାମ '''ଆଭୋଡାର୍ଟ'''/ '''Avodart''') ଏକ ଔଷଧ ଯାହା [[ବିନାଇନ ପ୍ରୋସ୍ଟାଟିକ ହାଇପରପ୍ଲାସିଆ|ବର୍ଦ୍ଧିତ ପ୍ରୋସ୍ଟେଟ]] ରୋଗର ଲକ୍ଷଣମାନଙ୍କର ଚିକିତ୍ସା ନିମନ୍ତେ ଦିଆଯାଏ ।<ref name=AHFS2019/><ref name=BNF76>{{cite book|title=British national formulary : BNF 76|date=2018|publisher=Pharmaceutical Press|isbn=9780857113382|pages=769|edition=76}}</ref> ଏହାର ଉପକାରୀତା ପ୍ରାୟ କିଛି ମାସ ପରେ ଜଣାଯାଏ ।<ref name=BNF76/> ଏହା ବ୍ୟତୀତ ପୁରୁଷଙ୍କର ମୁଣ୍ଡ ବାଳ ଝଡ଼ିବାର ଚିକିତ୍ସା ନିମନ୍ତେ ଓ ମହିଳାଙ୍କର [[ଟ୍ରାନ୍ସଜେଣ୍ଡର ହରମୋନ ଥେରାପି (ପୁରୁଷରୁ ମହିଳା)|ହରମୋନ ଥେରାପି]]ରେ ([[:en:transgender hormone therapy (male-to-female)|hormone therapy]]) ବ୍ୟବହାର କରାଯାଏ ।<ref name="ShapiroOtberg2015">{{cite book|author1=Jerry Shapiro|author2=Nina Otberg|title=Hair Loss and Restoration, Second Edition|url=https://books.google.com/books?id=bJG9BwAAQBAJ&pg=PA39|date=17 April 2015|publisher=CRC Press|isbn=978-1-4822-3199-1|pages=39–}}</ref><ref name=Trans2017>{{cite journal | vauthors = Wesp LM, Deutsch MB | title = Hormonal and Surgical Treatment Options for Transgender Women and Transfeminine Spectrum Persons | journal = Psychiatr. Clin. North Am. | volume = 40 | issue = 1 | pages = 99–111 | year = 2017 | pmid = 28159148 | doi = 10.1016/j.psc.2016.10.006 | url = }}</ref> ଏହା ପାଟିରେ ଦିଆଯାଏ ।<ref name=AHFS2019>{{cite web |title=Dutasteride Monograph for Professionals |url=https://www.drugs.com/monograph/dutasteride.html |website=Drugs.com |publisher=American Society of Health-System Pharmacists |accessdate=18 March 2019 |language=en}}</ref><ref name=Wu2013>{{cite journal | vauthors = Wu C, Kapoor A | title = Dutasteride for the treatment of benign prostatic hyperplasia | journal = Expert Opin Pharmacother | volume = 14 | issue = 10 | pages = 1399–408 | year = 2013 | pmid = 23750593 | doi = 10.1517/14656566.2013.797965 | url = }}</ref>
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Common side effects include sexual problems, breast tenderness, and breast enlargement.<ref name=AHFS2019/> Other side effects include an increased risked of certain forms of [[prostate cancer]], [[depression (mood)|depression]], and [[angioedema]].<ref name=AHFS2019/><ref name=BNF76/> Exposure during [[pregnancy]], including use by the partner of a pregnant women may result in harm to the body.<ref name=AHFS2019/><ref name=BNF76/> Dutasteride is a [[5α-reductase inhibitor]], and hence is a type of [[antiandrogen]].<ref name=Blu2008>{{cite book|author1=Ulrike Blume-Peytavi|author2=David A. Whiting|author3=Ralph M. Trüeb|title=Hair Growth and Disorders|url=https://books.google.com/books?id=pHrX2-huQCoC&pg=PA369|date=26 June 2008|publisher=Springer Science & Business Media|isbn=978-3-540-46911-7|pages=182, 369}}</ref> It works by [[enzyme inhibitor|decreasing]] the [[biosynthesis|production]] of [[dihydrotestosterone]] (DHT), an [[androgen]] [[sex hormone]].<ref name=Agg2010>{{cite journal | vauthors = Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M | title = An overview on 5alpha-reductase inhibitors | journal = Steroids | volume = 75 | issue = 2 | pages = 109–53 | date = February 2010 | pmid = 19879888 | doi = 10.1016/j.steroids.2009.10.005 }}</ref><ref name=AHFS2019/>▼
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Dutasteride was patented in 1993 by [[GlaxoSmithKline]] and was approved for medical use in 2001.<ref name=Fis2006>{{cite book |last1=Fischer |first1=Jnos |last2=Ganellin |first2=C. Robin |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=483 |url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA483 |language=en}}</ref><ref name=AHFS2019/> It is avaliable as a [[generic medication]].<ref name=BNF76/> A month supply in the United Kingdom costs the [[NHS]] about 12 £ as of 2019.<ref name=BNF76/> In the United States the wholesale cost of this amount is about 6.66 USD.<ref name=NADAC2019>{{cite web |title=NADAC as of 2019-02-27 |url=https://data.medicaid.gov/Drug-Pricing-and-Payment/NADAC-as-of-2019-02-27/s7c9-pfa6 |website=Centers for Medicare and Medicaid Services |accessdate=3 March 2019 |language=en}}</ref> In 2016 it was the 274th most prescribed medication in the United States with more than a million prescriptions.<ref>{{cite web |title=The Top 300 of 2019 |url=https://clincalc.com/DrugStats/Top300Drugs.aspx |website=clincalc.com |accessdate=22 December 2018}}</ref>
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