ଫ୍ଲୁଭୋକ୍ସାମାଇନ

ଫ୍ଲୁଭୋକ୍ସାମାଇନ
Clinical data
Trade names	Luvox, Faverin, Fluvoxin, others
AHFS/Drugs.com	monograph
MedlinePlus	a695004
data	EU EMA: yes; US DailyMed: Fluvoxamine;
Pregnancy; category	AU: C ; US: C (Risk not ruled out) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; CA: ℞-only ; UK: POM (Prescription only) ; US: ℞-only ;
Pharmacokinetic data
Bioavailability	53% (90% confidence interval: 44–62%)
Protein binding	77–80%
Metabolism	Hepatic (via cytochrome P450 enzymes. Mostly via oxidative demethylation)
Elimination half-life	12–13 hours (single dose), 22 hours (repeated dosing)
Excretion	Kidney (98%; 94% as metabolites, 4% as unchanged drug)
Identifiers
	IUPAC name 2-{[(E)-{5-Methoxy-1-[4-(trifluoromethyl)phenyl]; pentylidene}amino]oxy}ethanamine;
ECHA InfoCard	100.125.476
Chemical and physical data
Formula	C15H21F3N2O2
Molar mass	318.335
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c1ccc(\C(=N\OCCN)CCCCOC)cc1;
	InChI InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+ ; Key:CJOFXWAVKWHTFT-XSFVSMFZSA-N ;
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ଫ୍ଲୁଭୋକ୍ସାମାଇନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବିକ୍ରୟ ନାମ ଲୁଭକ୍ସ, ହେଉଛି ଏକ ସିଲେକ୍ଟିଭ୍ ସେରୋଟୋନିନ୍ ରିଅପଟେକ୍ ଇନହିବିଟର (SSRI) ଶ୍ରେଣୀର ଔଷଧ ।^[୫] ଏହା ମୁଖ୍ୟତଃ ଅବସେସିଭ୍-କମ୍ପଲସିଭ ଡିଜଅର୍ଡ଼ର ରୋଗର (OCD) ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୫] ପ୍ରମୁଖ ଅବସାଦ ବେମାରୀ, ବୁଲେମିଆ ଏବଂ ପ୍ୟାନିକ୍ ଡିଜଅର୍ଡର୍, ସାମାଜିକ ଚିନ୍ତା ବ୍ୟାଧି ଏବଂ ଆଘାତୋତ୍ତର ଚାପ ବେମାରୀ ଭଳି ରୋଗମାନଙ୍କରେ ମଧ୍ୟ ଏହା ବ୍ୟବହାର ହୁଏ ।^[୬] ^[୭] ^[୮] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୫]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ନିଦ୍ରାଳୁ ଭାବ, ଯୌନ ସମସ୍ୟା, ଝାଳ ଏବଂ ଉତ୍ତେଜନା ହୋଇପାରେ ।^[୫] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ୨୫ ବର୍ଷରୁ କମ୍ ବୟସରେ ଆତ୍ମହତ୍ୟା ହେବାର ଆଶଙ୍କା ଏବଂ ଯକୃତ ଜନିତ ସମସ୍ୟା ହୋଇପାରେ ।^[୫] ^[୬] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର ଅସ୍ପଷ୍ଟ ସୁରକ୍ଷା ଅଟେ ।^[୫] ଫ୍ଲୁଭକ୍ସାମାଇନ୍ ବ୍ୟବ‌ହାର ପାଇଁ ସ୍ତନ୍ୟପାନ ବନ୍ଦ କରିବା ଆବଶ୍ୟକ ନୁହେଁ । ^[୯]

୧୯୯୪ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ଫ୍ଲୁଭକ୍ସାମାଇନ୍ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୫] ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ଏହାର ନାମ ଲିପିବଦ୍ଧ ଅଛି । ^[୧୦] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ଅଛି ।^[୬] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୦ ସୁଦ୍ଧା ଦୈନିକ ୧୦୦ମିଗ୍ରାର ସାଧାରଣ ମାତ୍ରା ପାଇଁ ପ୍ରତି ମାସରେ ପ୍ରାୟ ୧୮ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୋଇଥାଏ ।^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ୨୦୨୧ ସୁଦ୍ଧା ପ୍ରାୟ ୧୫ ଡଲାର ଥିଲା ।^[୧୧]

↑ ^୧.୦ ^୧.୧ Use During Pregnancy and Breastfeeding
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Product Information Luvox". TGA eBusiness Services. Abbott Australasia Pty Ltd. 15 January 2013. Archived from the original on 9 October 2017. Retrieved 21 October 2013.
↑ van Harten J (March 1993). "Clinical pharmacokinetics of selective serotonin reuptake inhibitors". Clinical Pharmacokinetics. 24 (3): 203–20. doi:10.2165/00003088-199324030-00003. PMID 8384945. S2CID 84636672.
↑ "Luvox". ChemSpider. Royal Society of Chemistry. Archived from the original on 15 ନଭେମ୍ବର 2013. Retrieved 21 ଅକ୍ଟୋବର 2013.
↑ ^୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ "FluvoxaMINE Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 14 April 2021.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 384. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)
↑ Figgitt DP, McClellan KJ (October 2000). "Fluvoxamine. An updated review of its use in the management of adults with anxiety disorders". Drugs. 60 (4): 925–54. doi:10.2165/00003495-200060040-00006. PMID 11085201.
↑ Irons J (December 2005). "Fluvoxamine in the treatment of anxiety disorders". Neuropsychiatric Disease and Treatment. 1 (4): 289–99. PMC 2424117. PMID 18568110.
↑ "Fluvoxamine use while Breastfeeding". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 15 April 2021.
↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
↑ "Fluvoxamine Prices, Coupons & Savings Tips". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 15 April 2021.

[Drugs.com_pregnancy-1] ୧.୦ ^୧.୧ Use During Pregnancy and Breastfeeding

[LUVOX-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ "Product Information Luvox". TGA eBusiness Services. Abbott Australasia Pty Ltd. 15 January 2013. Archived from the original on 9 October 2017. Retrieved 21 October 2013.

[3] van Harten J (March 1993). "Clinical pharmacokinetics of selective serotonin reuptake inhibitors". Clinical Pharmacokinetics. 24 (3): 203–20. doi:10.2165/00003088-199324030-00003. PMID 8384945. S2CID 84636672.

[4] "Luvox". ChemSpider. Royal Society of Chemistry. Archived from the original on 15 ନଭେମ୍ବର 2013. Retrieved 21 ଅକ୍ଟୋବର 2013.

[AHFS2021-5] ୫.୦ ^୫.୧ ^୫.୨ ^୫.୩ ^୫.୪ ^୫.୫ ^୫.୬ "FluvoxaMINE Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 14 April 2021.

[BNF80-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ BNF (80 ed.). BMJ Group and the Pharmaceutical Press. September 2020 – March 2021. p. 384. ISBN 978-0-85711-369-6.{{cite book}}: CS1 maint: date format (link)

[7] Figgitt DP, McClellan KJ (October 2000). "Fluvoxamine. An updated review of its use in the management of adults with anxiety disorders". Drugs. 60 (4): 925–54. doi:10.2165/00003495-200060040-00006. PMID 11085201.

[8] Irons J (December 2005). "Fluvoxamine in the treatment of anxiety disorders". Neuropsychiatric Disease and Treatment. 1 (4): 289–99. PMC 2424117. PMID 18568110.

[Breast2021-9] "Fluvoxamine use while Breastfeeding". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 15 April 2021.

[WHO22nd-10] World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.

[GX2021-11] "Fluvoxamine Prices, Coupons & Savings Tips". GoodRx (in ଆମେରିକୀୟ ଇଂରାଜୀ). Archived from the original on 8 May 2021. Retrieved 15 April 2021.

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