ପ୍ରୋପାଫେନୋନ

ପ୍ରୋପାଫେନୋନ
Clinical data
Pronunciation	/proʊˈpæfɪnoʊn/ proh-PAF-i-nohn
Trade names	Rythmol, Rytmonorm, others
AHFS/Drugs.com	monograph
MedlinePlus	a698002
data	US DailyMed: Propafenone;
Pregnancy; category	US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	US: ℞-only ;
Pharmacokinetic data
Protein binding	97%
Elimination half-life	2–10 hours
Identifiers
	IUPAC name 1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one;
ECHA InfoCard	100.053.578
Chemical and physical data
Formula	C21H27NO3
Molar mass	୩୪୧.୪୫ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(c1ccccc1OCC(O)CNCCC)CCc2ccccc2;
	InChI InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3 ; Key:JWHAUXFOSRPERK-UHFFFAOYSA-N ;
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ପ୍ରୋପାଫେନୋନ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ରାଇଥମୋଲ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ସୁପ୍ରାଭେଣ୍ଟ୍ରିକୁଲାର ଏବଂ ଭେଣ୍ଟ୍ରିକୁଲାର ଟାକିଆରିଥମିଆ ରୋଗମାନଙ୍କର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୨] ଏହାର ଦୀର୍ଘକାଳୀନ ବ୍ୟବହାର ସାଧାରଣତଃ ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୩] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୨]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଅଇ, ମୁଣ୍ଡ ବୁଲାଇବା, ମୁଣ୍ଡବିନ୍ଧା, ଅସ୍ପଷ୍ଟ ଦୃଷ୍ଟିଶକ୍ତି, ଅଣନିଶ୍ୱାସ ଏବଂ ଯକୃତ ସମସ୍ୟା ହୋଇପାରେ ।^[୨] ଅନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ହୃଦ୍‌ପାତ, ଅନ୍ୟାନ୍ୟ ଆରିଦମିଆ ଏବଂ ସ୍ୱଳ୍ପ ଶ୍ୱେତ ରକ୍ତ କଣିକା ହୋଇପାରେ ।^[୨] ଗଠନମୂଳକ ହୃଦ୍‌ରୋଗ ବା ଇସକେମିକ୍ ହୃଦ୍‌ରୋଗ ଥିବା ଲୋକଙ୍କଠାରେ ବ୍ୟବହାର ସୁପାରିଶ କରାଯାଏ ନାହିଁ ।^[୨] ଏହା ଏକ ଶ୍ରେଣୀ ୧ଗ ଆଣ୍ଟି-ଆରିଦମିକ୍ ଔଷଧ ।^[୨]

୧୯୮୯ ମସିହାରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଚିକିତ୍ସା ବ୍ୟବହାର ପାଇଁ ପ୍ରୋପାଫେନୋନ ଅନୁମୋଦିତ ହୋଇଥିଲା ।^[୨] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।^[୪] ଯୁକ୍ତରାଜ୍ୟରେ ଏକ ସାଧାରଣ ମାତ୍ରାର ମାସକୁ ୭ ପାଉଣ୍ଡ ଖର୍ଚ୍ଚ ହୁଏ ।^[୪] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ପରିମାଣ ମାସକୁ ଖର୍ଚ୍ଚ ୧୫ ଡଲାର ଅଟେ ।^[୫] ଏକ ଲମ୍ବା ଫର୍ମୁଲା ମଧ୍ୟ ଉପଲବ୍ଧ ।^[୨]

ଆଧାର ସମ୍ପାଦନା

↑ "Propafenone Use During Pregnancy". Drugs.com. 13 November 2018. Archived from the original on 7 February 2020. Retrieved 7 February 2020.
↑ ^୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ "Propafenone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 29 October 2021.
↑ Bersten, Andrew D.; Handy, Jonathan (15 August 2018). Oh's Intensive Care Manual E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 271. ISBN 978-0-7020-7606-0. Archived from the original on 30 October 2021. Retrieved 29 October 2021.
↑ ^୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 112. ISBN 978-0857114105.
↑ "Propafenone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 29 October 2021.

[Drugs.com_pregnancy-1] "Propafenone Use During Pregnancy". Drugs.com. 13 November 2018. Archived from the original on 7 February 2020. Retrieved 7 February 2020.

[AHFS2021-2] ୨.୦ ^୨.୧ ^୨.୨ ^୨.୩ ^୨.୪ ^୨.୫ ^୨.୬ ^୨.୭ "Propafenone Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 21 January 2021. Retrieved 29 October 2021.

[3] Bersten, Andrew D.; Handy, Jonathan (15 August 2018). Oh's Intensive Care Manual E-Book (in ଇଂରାଜୀ). Elsevier Health Sciences. p. 271. ISBN 978-0-7020-7606-0. Archived from the original on 30 October 2021. Retrieved 29 October 2021.

[BNF81-4] ୪.୦ ^୪.୧ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 112. ISBN 978-0857114105.

[5] "Propafenone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Retrieved 29 October 2021.

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Clinical data


Pronunciation	/proʊˈpæfɪnoʊn/ proh-PAF-i-nohn
Trade names	Rythmol, Rytmonorm, others
AHFS/Drugs.com	monograph
MedlinePlus	a698002
data	US DailyMed: Propafenone
Pregnancy category	US: N (Not classified yet) ^[୧]
Routes of administration	By mouth
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Protein binding	97%
Elimination half-life	2–10 hours
Identifiers
IUPAC name 1-{2-[2-Hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one
ECHA InfoCard	100.053.578
Chemical and physical data
Formula	C₂₁H₂₇NO₃
Molar mass	୩୪୧.୪୫ g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(c1ccccc1OCC(O)CNCCC)CCc2ccccc2
InChI InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3^Y Key:JWHAUXFOSRPERK-UHFFFAOYSA-N^Y
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