ଓଲାପାରିବ

ଓଲାପାରିବ
Clinical data
Trade names	Lynparza, others
Synonyms	AZD-2281, MK-7339, KU0059436
AHFS/Drugs.com	monograph
MedlinePlus	a614060
data	EU EMA: yes; US DailyMed: Olaparib;
Pregnancy; category	AU: D ; US: N (Not classified yet) ; ;
Routes of; administration	By mouth
Legal status
Legal status	AU: S4 (Prescription only) ; UK: POM (Prescription only) ; US: ℞-only ; EU: Rx-only ; ℞ (Prescription only);
Identifiers
	IUPAC name 4-[(3-[(4-cyclopropylcarbonyl)piperazin-1-yl]carbonyl) -4-fluorophenyl]methyl(2H)phthalazin-1-one;
ECHA InfoCard	100.170.811
Chemical and physical data
Formula	C24H23FN4O3
Molar mass	୪୩୪.୪୭ g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c4cccc2c4c(n[nH]c2=O)Cc(ccc1F)cc1C(=O)N3CCN(CC3)C(=O)C5CC5;
	InChI InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30) ; Key:FDLYAMZZIXQODN-UHFFFAOYSA-N ;
(verify)

ଓଲାପାରିବ, ଏକ ବେପାର ନାମ ଲିନପର୍ଜା, ହେଉଛି ଏକ ଔଷଧ ଯାହା ଓଭାରି କର୍କଟ, ଫାଲୋପିଆନ ଟ୍ୟୁବ୍ କର୍କଟ ଏବଂ ପେରିଟୋନିଆଲ୍ କର୍କଟ ରୋଗର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ^[୬] ଅନ୍ୟାନ୍ୟ ଚିକିତ୍ସାରେ ବିଫଳ ହୋଇଥିବା ଏବଂ ସମ୍ଭବତଃ ବିଆରସିଏ (BRCA) ଯୁକ୍ତାତ୍ମକ ମ୍ୟୁଟେସନ୍ ରୋଗୀଙ୍କ କ୍ଷେତ୍ରରେ ବ୍ୟବହୃତ ହୁଏ ।^[୪] ଏହା ପାଟିରେ ଦିଆଯାଏ ।^[୬]

ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଥକ୍କା, ବାନ୍ତି, ତରଳ ଝାଡ଼ା, ବୁକୂଜ୍ୱାଳା, କାଶ, ମୁଣ୍ଡବିନ୍ଧା, ଅଣନିଶ୍ୱାସ, ସ୍ୱଳ୍ପ ଧଳା ରକ୍ତ କଣିକା ଏବଂ କମ୍ ରକ୍ତ ପ୍ଲାଟେଲେଟ ହୋଇପାରେ ।^[୭] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ମାୟେଲୋଡିସପ୍ଲାଷ୍ଟିକ ସିଣ୍ଡ୍ରୋମ ଏବଂ ନିମୋନିଆ ହୋଇପାରେ ।^[୪] ସ୍ତନ୍ୟପାନ କରାଇବା କିମ୍ବା ଗର୍ଭବତୀ ଥିବା ସମୟରେ ଏହାକୁ ବ୍ୟବହାର କରିବା ଉଚିତ୍ ନୁହେଁ ।^[୭] ^[୪] ଏହା ଏକ ପିଏଆରପି (PARP) ପ୍ରତିବନ୍ଧକ ଏବଂ କର୍କଟ କୋଷଗୁଡ଼ିକର ଡିଏନଏ ମରାମତି କରିବାର କ୍ଷମତାକୁ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।^[୬]

୨୦୧୪ ମସିହାରେ ୟୁରୋପ ଏବଂ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଡାକ୍ତରୀ ବ୍ୟ‌ବ‌ହାର ପାଇଁ ଓଲାପାରିବକୁ ଅନୁମୋଦନ କରାଯାଇଥିଲା ।^[୪] ^[୭] ୨୦୨୧ ମସିହାରେ ଯୁକ୍ତରାଜ୍ୟରେ ଏହାର ଦୈନିକ ୨ଥର ୩୦୦ ମିଗ୍ରା ମାତ୍ରାର ୪ ସପ୍ତାହର ଖର୍ଚ୍ଚ ପ୍ରାୟ ୪୬୦୦ ପାଉଣ୍ଡ ଥିଲା । ^[୬] ଯୁକ୍ତରାଷ୍ଟ୍ରର ଏହି ପରିମାଣର ମୂଲ୍ୟ ପ୍ରାୟ ୧୪,୦୦୦ ଡଲାର ଥିଲା ।^[୮]

ଆଧର ସମ୍ପାଦନା

↑ "Lynparza EPAR". European Medicines Agency (EMA). Archived from the original on 24 September 2020. Retrieved 6 October 2020.
↑ "Lynparza 50 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 7 October 2019. Archived from the original on 23 September 2020. Retrieved 13 April 2020.
↑ "Lynparza 100mg Film-Coated Tablets - Summary of Product Characteristics (SmPC)". (emc). 7 October 2019. Archived from the original on 26 September 2020. Retrieved 13 April 2020.
↑ ^୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Lynparza- olaparib capsule". DailyMed. 27 September 2018. Archived from the original on 26 October 2021. Retrieved 30 December 2019.
↑ "Lynparza- olaparib tablet, film coated". DailyMed. 1 June 2019. Archived from the original on 25 October 2021. Retrieved 30 December 2019.
↑ ^୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1051. ISBN 978-0857114105.
↑ ^୭.୦ ^୭.୧ ^୭.୨ "Lynparza EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 24 September 2020. Retrieved 13 April 2020.
↑ "Lynparza Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 7 November 2021.

[1] "Lynparza EPAR". European Medicines Agency (EMA). Archived from the original on 24 September 2020. Retrieved 6 October 2020.

[2] "Lynparza 50 mg hard capsules - Summary of Product Characteristics (SmPC)". (emc). 7 October 2019. Archived from the original on 23 September 2020. Retrieved 13 April 2020.

[3] "Lynparza 100mg Film-Coated Tablets - Summary of Product Characteristics (SmPC)". (emc). 7 October 2019. Archived from the original on 26 September 2020. Retrieved 13 April 2020.

[PI2021-4] ୪.୦ ^୪.୧ ^୪.୨ ^୪.୩ ^୪.୪ ^୪.୫ "Lynparza- olaparib capsule". DailyMed. 27 September 2018. Archived from the original on 26 October 2021. Retrieved 30 December 2019.

[Lynparza_tablet_PI-5] "Lynparza- olaparib tablet, film coated". DailyMed. 1 June 2019. Archived from the original on 25 October 2021. Retrieved 30 December 2019.

[BNF81-6] ୬.୦ ^୬.୧ ^୬.୨ ^୬.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 1051. ISBN 978-0857114105.

[EPAR2021-7] ୭.୦ ^୭.୧ ^୭.୨ "Lynparza EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 24 September 2020. Retrieved 13 April 2020.

[8] "Lynparza Prices, Coupons & Patient Assistance Programs". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 16 January 2021. Retrieved 7 November 2021.

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